ARHGEF7 (Vector pUC, Accession No. BC060776)

Length: 2412 Sequence: atgaattccg ccgagcaaac cgttacgtgg ctcatcactc tgggggtgct ggagtcgccc aaaaaaacca tctcggaccc ggagggcttt ctgcaggcgt cgctgaagga tggggtggtc ctctgcaggc tgctggagcg cctgctcccc gggaccatcg agaaagtcta ccccgagccc cggagcgaga gcgagtgcct gagcaacatc cgcgagttcc tgcgcggctg cggggcttcc ctgcggctgg agctcctgtt tcctccttcc cagcctcctc agcatctggt aaccaccatt ctcttgtctg cttctacgtt tgatgcaaat gatttgtatc aggggcagaa ttttaacaag gtcctcagtt ccttagtgac tctaaataaa gtaacagcag acatcgggct ggggagtgac tccgtgtgtg cccggccctc gtctcaccgc ataaagtctt ttgactccct tggatcacag tctttgcaca ctcggacttc aaaactgttc cagggccagt atcggagttt ggacatgacc gataatagca acaatcaact ggtagtaaga gcaaagttta acttccagca gaccaatgag gacgagcttt ccttctcaaa aggagacgtc atccatgtca cccgtgtgga agagggaggc tggtgggagg gcacactcaa cggccggacc ggctggttcc ccagcaacta cgtgcgcgag gtcaaggcca gcgagaagcc tgtgtctccc aaatcaggaa cactgaagag ccctcccaaa ggatttgata cgactgccat aaacaaaagc tattacaatg tggtgctaca gaatatttta gaaacagaaa atgaatattc taaagaactt cagactgtgc tttcaacgta cctacggcca ttgcagacca gtgagaagtt aagttcagca aacatttcat atttaatggg aaatctagaa gaaatatgtt ctttccagca aatgctcgta cagtctttag aagaatgcac caagttgccc gaagctcagc agagagtcgg aggctgcttt ttaaacctga tgccacagat gaaaaccctg tacctcacgt attgtgccaa tcacccttct gcagtgaatg tcctcacgga acacagtgag gagttggggg agttcatgga gaccaaaggt gccagcagcc ctgggattct cgtgctgacc acgggcctga gcaaaccctt catgcgcctg gataaatacc ctacgctgct caaagagctc gagagacaca tggaggatta tcatacagat agacaagata ttcaaaaatc catggctgcc ttcaaaaacc tttcagccca atgtcaagaa gtccggaaga ggaaagagct tgagctgcag atcctgacgg aagccatccg gaactgggag ggcgatgaca ttaaaactct gggcaacgtc acttacatgt cccaggtcct gattcagtgt gccggaagtg aggaaaagaa tgaaagatat cttctactct tcccaaatgt tttgctaatg ttgtctgcca gtcctaggat gagtggcttt atctatcagg gaaagcttcc aacgacagga atgacaatca caaagcttga ggacagtgaa aatcatagaa atgcatttga aatatcaggg agcatgattg agcggatatt agtgtcgtgc aacaaccagc aggatctgca ggaatgggtg gagcacctac agaagcaaac gaaggtcacg tctgtgggaa accccaccat aaagcctcat tcagtgccat ctcataccct cccctcccac ccggtcactc cgtccagcaa gcacgcagac agcaagcccg cgccgctgac gcccgcctac cacacgctgc cccacccctc ccaccacggc accccgcaca ccaccatcaa ctggggaccc ctggagcctc cgaaaacacc caagccctgg agcctgagct gcctgcggcc cgcgcctccc ctccggccct cagctgctct ctgctacaag gaggatctta gtaagagccc taagaccatg aaaaagctgc tgcccaagcg caaacctgaa cggaagcctt cagatgagga gttcgcgtcc cggaaaagca cagctgcttt ggaagaagat gctcagattc tgaaagtcat tgaagcttac tgcaccagcg ccaaaacaag gcaaacactc aattcaacat ggcaaggcac tgacctgatg cataatcacg tcttggctga tgatgaccaa ccaagcctag actccctggg gcgtcgcagt agcctttctc gtttggagcc ttcagacctc tcggaagact ctgactatga cagtatatgg acagcccata gttacagaat gggttctaca tctcgtaaga gctgttgctc atatatctct caccagaact Protein function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. [The UniProt Consortium]