ARHGAP24 (Vector pUC, Accession No. BC047918)

Length: 741 Sequence: atggaggaga acaatgactc cacggagaac ccccaacaag gccaagggcg gcagaatgcc atcaagtgtg ggtggctgag gaagcaagga ggctttgtca agacttggca tactcgctgg tttgtgctca agggggatca gctctattat ttcaaagatg aagatgaaac caagcccttg ggtactattt ttctgcctgg aaataaagtt tctgagcatc cctgcaatga agagaaccca gggaagttcc tttttgaagt agttccagga ggcgatcgag atcggatgac agcaaatcat gagagctacc tcctcatggc aagcacccag aatgatatgg aagactgggt gaagtcaatc cgccgagtca tatggggacc tttcggagga ggcatttttg gacagaaact ggaggatact gttcgttatg agaagagata tgggaaccgt ctggctccga tgttggtgga gcagtgcgtg gactttatcc gacaaagggg gctgaaagaa gagggtctct ttcgactgcc aggccaggct aatcttgtta aggagctcca agatgccttt gactgtgggg agaagccatc atttgacagc aacacagatg tacacacggt ggcatcactt cttaagctgt acctccgaga acttccagaa ccagttattc cttatgcgaa gtatgaagat tttttgtcat gtgccaaact gctcagcaag gaagaggaag cagtaagttg Protein function: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. [The UniProt Consortium]