ARHGAP22 (Vector pUC, Accession No. BC126444)

Length: 2145 Sequence: atgctgagcc caaagatcag gcaggccagg agggcccgct ccaaaagcct agtgatgggg gagcagagcc ggagccctgg gcggatgccg tgccctcaca ggctgggccc cgtgctgaag gcgggctggc tgaagaagca gaggagcatc atgaagaact ggcagcagcg ctggtttgtg ctgcgtgggg atcagctttt ctactacaag gacaaagatg agatcaagcc ccagggattt atttctctac aagggacaca ggtgactgaa cttcctcctg gccccgagga cccagggaag cacctctttg agatcagccc aggtggtgct ggggagcggg agaaggtgcc ggccaacccc gaggcgctcc tgctcatggc cagctcccag cgtgacatgg aggactgggt gcaggccatc cgccgagtca tctgggcccc gctgggcgga ggtactgccc gtagatcgca tgcccaccct ctagaaccct tgcctccagg gatctttggg cagcgcctag aggaaacagt ccaccacgag cggaagtatg gcccccgcct ggcgcccctg ctggtggagc agtgtgtgga cttcatccgg gagcgcgggc tcactgagga ggggctgttc cgcatgccgg gccaggccaa cctggtgagg gacctgcagg attccttcga ctgtggggag aagccactgt ttgacagcac aacagacgtg cacacggtgg cctccctgct gaagctgtac ctgcgggagc tccccgagcc cgtggtcccc ttcgccaggt acgaggactt cctcagctgc gcccagctgc tcaccaagga cgagggggag ggcactctgg agttggctaa acaagtgagc aaccttcctc aggcaaatta caacctgctc agatacatct gcaagtttct ggatgaagtt caggcatact caaatgtcaa caagatgagt gtccagaatc tggcaaccgt ttttggacct aacattctgc ggccacaggt agaggaccca gtaaccatca tggaaggcac ttccctcgtc cagcacctga tgaccgtcct catccgcaaa cacagccagc tcttcacggc accggtcccg gaagggccca cctccccgcg cgggggcctg caatgcgcag tggggtgggg ctccgaggag gtcaccaggg acagccaagg agagcccggc ggccccggcc tgcccgcgca caggacctct tccctggacg gggcggccgt ggcggtgctc tccagaacag cccccacggg gccggggagc cggtgcagcc ctgggaagaa ggtgcagacc ctgcccagtt ggaagtcctc cttccggcag ccgaggtccc tatcgggaag cccgaagggg ggcggctcat ccctggaggt gcccatcatc tcctccggcg ggaactggct tatgaacggg ctgtcctccc tgcgcggaca ccgccgggcc tcgtcgggag accggctcaa ggactcgggc tccgtgcaga gactctccac ctacgacaat gtgcccgcgc cgggcctggt ccccggcata cccagcgtgg ccagtatggc gtggtccggg gcctcgtcca gcgagtcgtc ggtggggggc tcactcagca gctgcacggc ctgccgcgcc agcgactcgt ctgcccgcag ttccctgcac accgactggg ccctggagcc ctccccgctc cccagcagca gcgaggaccc caagtccctg gacctggacc acagcatgga cgaggcgggc gcgggtgcca gcaacagcga gcccagcgag ccggacagcc ccacccggga acacgcgcgc cgctccgagg ccttacaggg gctggtcact gagctcaggg ccgagctgtg ccgccagcgg actgagtacg agaggagtgt gaaaagaatc gaagaaggga gtgctgacct gagaaaacga atgtcccggt tagaagaaga actggaccag gaaaagaaaa aatacatcat gctggaaata aagctgcgga actctgaacg ggcgcgggag gatgcggaga ggaggaacca gctgttgcag agggaaatgg aggagttttt ttcgacccta ggaagcttga ctgttggggc aaaaggtgcc agggccccaa Protein function: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. [The UniProt Consortium]