ARHGAP17 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 348 Sequence: atgcacacca aacccaatag ccagggccct cccaacccca tggcattgcc cagtgagcat ggacttgagc agccatctca cacccctccc cagactccaa cgccccccag tactccgccc ctaggaaaac agaaccccag tctgccagct cctcagaccc tggcaggggg taaccctgaa actgcacagc cacatgctgg aaccttaccg agaccgagac cagtaccaaa gccaaggaac cggcccagcg tgcccccacc cccccaacct cctggtgtcc actcagctgg ggacagcagc ctcaccaaca cagcaccaac agcttccaag atagtaacag Protein function: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. [The UniProt Consortium]