ARFIP2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1026 Sequence: atgacggacg ggatcctagg gaaggcagcc acaatggaga tccctatcca cgggaacggc gaagccaggc agcttcctga agatgatggg ctggagcagg acctccagca ggtgatggtg tcaggaccca acctcaatga aaccagcatt gtgtctggtg gctatggggg ctctggtgat ggactcatcc ccacagggtc tggccgccat ccatctcaca gcaccactcc ttctggccct ggagatgagg tggctcgggg cattgctgga gaaaagtttg acatcgtcaa gaaatggggc atcaacacct ataagtgcac aaagcaactg ttatcagaac gatttggtcg aggctcacgg actgtggacc tggagctaga gctgcagatt gagttgctgc gtgagacgaa gcgcaagtat gagagtgtcc tgcagctggg ccgggcactg acagcccacc tctacagcct gctgcagacc cagcatgcac tgggtgatgc ctttgctgac ctcagccaga agtccccaga gcttcaggag gaatttggct acaatgcaga gacacagaaa ctactatgca agaatgggga aacgctgcta ggagccgtga acttctttgt ctctagcatc aacacattgg tcaccaagac catggaagac acgctcatga ctgtgaaaca gtatgaggct gccaggctgg aatatgatgc ctaccgaaca gacttagagg agctgagtct aggcccccgg gatgcaggga cacgtggtcg acttgagagt gcccaggcca ctttccaggc ccatcgggac aagtatgaga agctgcgggg agatgtggcc atcaagctca agttcctgga agaaaacaag atcaaggtga tgcacaagca gctgctgctc ttccacaatg ctgtgtccgc ctactttgct gggaaccaga aacagctgga gcagaccctg cagcagttca acatcaagct gcggcctcca ggagctgaga aaccctcctg gctagaggag Protein function: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658). [The UniProt Consortium]