APOBEC3B (Vector pENTR223.1, Accession No. BC053859)

Length: 756 Sequence: atgaatccac agatcagaaa tccgatggag cggatgtatc gagacacatt ctacgacaac tttgaaaacg aacccatcct ctatggtcgg agctacactt ggctgtgcta tgaagtgaaa ataaagaggg gccgctcaaa tctcctttgg gacacagggg tctttcgagg ccaggtgtat ttcgagcctc agtaccacgc agaaatgtgc ttcctctctt ggttctgtgg caaccagctg cctgcttaca agtgtttcca gatcacctgg tttgtatcct ggaccccctg cccggactgt gtggcgaagc tggccgaatt cctgtctgag caccccaatg tcaccctgac catctccgcc gcccgcctct actactactg ggaaagagat taccgaaggg cgctctgcag gctgagtcag gcaggagccc gcgtgaagat catggactat gaagaatttg catactgctg ggaaaacttt gtgtacaatg aaggtcagca attcatgcct tggtacaaat tcgatgaaaa ttatgcattc ctgcaccgca cgctaaagga gattctcagg ctaagaatct tctctgtggc ttttacggcc gccatgcgga gctgcgcttc ttggacctgg ttccttcttt gcagttggac ccggcccaga tctacagggt cacttggttc atctcctgga gcccctgctt ctcctggggc tgtgccgggg aagtgcgtgc gttccttcag gagaacacac Protein function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. [The UniProt Consortium]