AP4E1 (Vector pUC, Accession No. BC130466)

Length: 3414 Sequence: atgagcgaca tagtggagaa gacgctgacg gcgctgccgg gactctttct gcagaaccag cccggtggtg ggcccgcggc cgccaaggcg tccttctcct cgaggctggg cagccttgtc cgcggcatca cagccctcac ctccaagcac gaagaagaaa aattaatcca gcaggaactg agtagtctga aagcgactgt ttctgctcct actacaacac tgaaaatgat gaaggaatgt atggtgagac ttatatattg tgaaatgctt ggatatgatg cttcctttgg ctatattcat gcaatcaagt tagcccaaca aggaaacctc ttagaaaaaa gagtaggtta tttggctgtt tccttatttc tacatgaaag tcatgaatta ttgcttctcc ttgtgaatac agttgtaaag gatctgcaga gcactaacct agtagaagtg tgtatggcac tgactgttgt tagccagatt ttcccctgcg aaatgattcc agctgttctt ccattaatag aagataaact tcaacattct aaggagattg tacgaagaaa agctgttctg gcattataca aattccatct cattgctcct aatcaagtac aacatattca tattaagttt cggaaagcac tttgtgacag agatgttggg gtcatggctg cctccttgca tatatatctt agaatgatta aggagaattc atctggatat aaagacttga ctgggagttt tgtaaccatt ttgaagcaag tagttggagg aaagctccca gtagaattca attaccacag tgtgccagca ccatggttac aaattcagct cttgagaata ctgggacttc taggaaaaga tgatcaaagg acaagtgaat taatgtatga tgttcttgat gaatccttac gaagagctga gttaaatcac aatgtcacat atgctatttt gtttgaatgt gtgcatacag tctattctat ttatcctaaa tcggaattac ttgagaaggc tgccaagtgc attggaaaat ttgttctgtc acctaaaata aatctaaaat atttaggact gaaggctctt acctatgtta tccaacagga tcctactctg gctcttcaac accagatgac aataattgaa tgtttagatc atcctgatcc cattattaaa agagagactc tggaacttct ttacagaatt actaatgcac agaatataac agttattgtc cagaaaatgc ttgaatattt acatcagagc aaagaagagt atgtcatcgt caatttggtc ggcaaaatag cagagctggc tgagaaatat gctcctgata atgcatggtt tattcagaca atgaatgctg tgttttcagt aggaggagat gtaatgcatc ctgatattcc caataacttt ctgagactac tagcggaagg ttttgatgat gaaacagaag atcagcaatt aagactctat gcagttcagt cttatctcac tttactggat atggaaaatg tgttctatcc acagagattt cttcaagtta tgagttgggt attaggggaa tattcctacc tcttagataa ggaaacgcca gaggaagtta tagctaagct ctacaagtta cttatgaatg actctgtgtc ttcagaaaca aaagcctggt taattgctgc tgtgaccaaa ttgacatctc aggcgcactc ttctaataca gttgagagat taatccatga atttaccata tctttggata cttgtatgag acaacatgca tttgaattaa aacatttgca tgagaatgtg gaacttatga agagcttgct tccagttgac aggagttgtg aagacttggt ggtagatgct tctttatctt ttctggatgg ttttgtggct gaaggactca gtcagggtgc agcgccttac aaacctcccc atcaacgcca ggaggaaaag ctttctcagg aaaaagttct caattttgaa ccatatggac tctccttttc ttcatctggc ttcactggac gacagtctcc tgctggcatt tctcttggtt cagatgtatc tgggaatagt gctgagacag gactgaaaga gacaaatagc ttgaagctgg aaggtataaa gaaattgtgg gggaaagaag gctatcttcc caagaaggaa agcaaaactg gtgatgaaag tggagctctg cctgttcctc aagagagtat aatggagaat gtagatcaag ctataactaa aaaggatcaa tctcaagttc ttacccaatc taaagaggag aaagaaaagc agctgctggc atcatcatta tttgttggtc taggatcaga aagtacaatc aacctgctgg gaaaagcaga tactgtctct cacaagttca gaaggaaatc aaaagtcaaa gaagctaaaa gtggcgaaac aaccagtact cataatatga cctgttcttc ctttagttct ttgtcaaatg tggcatatga agatgattat tattcgaata ctttgcacga tacaggagac aaggaattaa agaaattttc tctcacttca gaacttttgg attctgagtc actcacagaa ctgcccttgg ttgagaaatt ctcatattgt agtctgtcta caccttcatt gtttgctaat aacaacatgg aaatttttca ccctcctcaa tctactgcag cctcagttgc caaggaaagc tctttagctt catctttttt ggaagaaact actgaataca tacactcaaa tgctatggaa gtctgtaata atgaaactat atcagtgtct tcttataaaa tttggaaaga tgattgttta ttgatggtct ggtcagtcac taataagagt ggtttggaat tgaaaagtgc tgacttagaa atttttcctg cagaaaattt caaggtgact gagcaacctg gatgctgttt gcctgtaatg gaagcagaaa gcaccaaaag ctttcaatat agtgtgcaga tagaaaaacc ttttacagaa ggaaatctta ctggttttat tagttatcat atgatggata ctcattctgc tcagctggaa ttttctgtaa acttatcact attagatttc attagaccat taaaaatctc aagtgacgac tttgggaaac tctggttatc cttcgcaaat gatgtgaaac aaaatgtaaa aatgtcagaa tctcaagctg cacttccttc tgcactaaag actctgcaac agaaactaag actccatatt attgagatta taggcaatga agggctattg gcctgtcagc tgctcccatc catcccctgc ttactgcatt gccgagttca tgcagatgta ttagccctgt ggttcagatc ctcctgttct actcttcctg actatttact gtatcagtgt caaaaggtga tggagggatc Protein function: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). [The UniProt Consortium]