ANKRD13D (Vector pUC, Accession No. BC110419)

Length: 1818 Sequence: ATGGCCGGCC CGGGCCCCAC CTTCCCGCTG CACCGGCTCG TCTGGGCGAA CCGGCATCGC GAACTGGAGG CCGCACTGCA CAGCCACCAG CACGACATTG AACAGGAGGA CCCCCGCGGG CGGACCCCAC TGGAGCTGGC CGTGTCTCTG GGAAACCTGG AGTCTGTGAG AGTGCTCCTT CGACACAATG CCAACGTGGG CAAAGAGAAC CGCCAGGGCT GGGCAGTCCT GCAGGAGGCA GTCAGCACTG GAGACCCCGA GATGGTGCAG CTGGTGCTCC AGTATCGGGA CTACCAGAGG GCCACGCAGA GGCTGGCGGG CATTCCGGAA CTGCTCAACA AACTTCGCCA GGCCCCCGAT TTCTACGTTG AGATGAAGTG GGAGTTCACC AGCTGGGTGC CCCTTGTGTC TAAGATGTGC CCAAGCGATG TGTACCGCGT GTGGAAGCGG GGTGAGAGCC TGCGAGTAGA CACCAGTCTC CTGGGCTTCG AGCACATGAC CTGGCAGCGG GGCCGGAGGA GCTTCATCTT CAAGGGCCAG GAGGCAGGAG CCCTGGTGAT GGAAGTGGAC CATGACCGGC AGGTGGTGCA TGTGGAGACA CTGGGGCTCA CTCTGCAGGA GCCCGAAACA CTGCTGGCCG CCATGCGGCC CAGCGAGGAG CATGTGGCCA GTCGCCTCAC CTCTCCTATC GTCTCCACCC ACCTGGACAC TCGTAATGTG GCCTTTGAGA GGAACAAATG TGGTATCTGG GGCTGGCGGT CTGAGAAGAT GGAAACTGTT AGCGGCTACG AGGCCAAGGT GTACAGTGCC ACCAACGTGG AGCTGGTGAC ACGCACACGC ACGGAGCACC TCTCTGATCA GGACAAGTCG AGGAGCAAAG CGGGGAAGAC TCCATTCCAG TCCTTCCTGG GGATGGCGCA GCAGCATTCC TCCCACACCG GGGCCCCCGT GCAGCAGGCA GCCAGCCCCA CCAACCCCAC AGCCATCTCC CCTGAGGAGT ACTTCGACCC CAACTTCAGC CTGGAGTCAC GGAACATTGG CCGCCCCATC GAGATGTCCA GCAAAGTACA GAGGTTCAAG GCAACACTGT GGCTGAGTGA AGAGCACCCG CTCTCCCTGG GTGACCAGGT GACCCCCATC ATCGACCTAA TGGCCATCAG CAACGCTCAC TTTGCCAAGC TGCGCGACTT CATCACTCTG CGCCTTCCAC CTGGCTTCCC CGTCAAAATT GAGATTCCCC TTTTCCACGT GCTCAATGCC CGCATCACCT TCAGCAACCT GTGTGGCTGT GATGAGCCCC TGAGCTCCGT GTGGGTGCCG GCCCCCAGCT CTGCTGTCGC CGCATCAGGG AACCCTTTCC CGTGCGAGGT GGACCCCACC GTGTTTGAAG TGCCCAACGG GTACAGCGTG CTGGGCATGG AGCGCAACGA GCCCCTCCGG GACGAGGACG ATGACCTCCT GCAGTTCGCC ATCCAGCAGA GCCTGCTTGA AGCGGGCACT GAGGCGGAGC AGGTGACCGT CTGGGAAGCC CTGACCAACA CCCGGCCCGG TGCCCGCCCT CCTCCCCAGG CCACGGTTTA TGAGGAACAG CTTCAGCTGG AGCGGGCCCT CCAGGAAAGC CTGCAGCTGT CCACAGAGCC CAGGGGCCCA GGATCCCCTC CCAGGACACC CCCAGCCCCC GGTCCACCCA GCTTTGAAGA GCAGCTGCGC CTGGCCCTGG AGTTCTCTTC ACGGGAGCAG GAGGAGCGGG AGCGGCGCGG GCAGCAGGAG GAGGAGGACT TACAGCGGAT CCTGCAGCTG TCACTCACTG Protein function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. [The UniProt Consortium]