ANAPC2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2469 Sequence: atggcggcgg cagttgtggt ggcggagggg gacagcgact cccggcccgg acaggagttg ttagtggcct ggaacaccgt gagcaccggc ctggtgccgc cggctgcgct ggggctggtg tcttcccgga ccagcggtgc agtcccgcca aaggaagagg agctccgggc ggcggtggag gttctgaggg gccacgggct acactcggtc ctggaggagt ggttcgtgga ggtgctgcag aacgatctgc aggccaacat ctcccctgag ttctggaatg ccatctccca atgcgagaac tctgcggatg agccccagtg ccttttgcta ctccttgacg cttttggcct gctggagagc cgcctggatc cctacctgcg tagcctagag ctgctggaga aatggactcg cctgggcttg ctgatgggca ctggtgctca ggggctgcga gaagaagtcc acactatgtt gcgcggagtc ttgttcttta gcacccccag aaccttccaa gagatgatcc agcgtctgta tgggtgcttc ttgagagtct atatgcagag taagaggaag ggggaagggg gcacagaccc ggaactggaa ggggagctgg acagccggta tgcccgtcgc cggtactacc ggctcctgca gagcccgctg tgtgcagggt gcagcagtga caagcaacag tgctggtgtc gccaggctct ggagcagttc catcagctca gccaggtctt acacaggctc agtctgctgg agcgggtcag tgccgaggct gtgaccacca ccctgcacca ggtgacccgg gagaggatgg aggaccgttg ccggggcgag tacgagcgct ccttcctgcg tgagttccac aagtggatcg agcgggtggt cggctggctc ggcaaggtgt tcctgcagga cggccccgcc aggcccgcat ctcccgaggc cggcaacacc ctgcgccgct ggcgctgcca cgtgcaaagg ttcttctacc gcatctacgc cagcctgcgc atcgaggagc tcttcagcat cgtccgagac ttcccagact cccggccagc catcgaggac ctcaagtact gcctggagag gacggaccag aggcagcagc tgctcgtgtc cctcaaggct gccctggaga ctcggctcct gcatccaggc gtcaacacgt gtgacatcat caccctctat atctctgcca tcaaggcgct gcgcgtgctg gacccttcca tggtcatcct ggaggtggcc tgtgagccta tccgccgcta cctgaggacg cgggaggaca cagtgcggca gattgtggct gggctgacgg gggactcgga cgggacaggg gacctggctg ttgagctgtc caagaccgac ccggcgagcc tggagacagg ccaggacagt gaggatgact caggcgagcc agaggactgg gtcccggacc ctgtggatgc cgatccaggg aagtcgagct ccaagcggcg ttcatcggac atcatcagcc tgctggtcag catctacggc agcaaggacc tcttcatcaa tgagtaccgc tcgctgctgg ccgaccgcct gctgcaccag ttcagcttca gccccgagcg ggagatccgc aacgtggagc tgctgaagct gcgctttggc gaggccccaa tgcacttctg tgaagtcatg ctgaaggaca tggcggactc ccgccgcatc aatgccaaca tccgggagga ggatgagaag cggccagcag aggagcagcc accgttcggg gtctacgctg tcatcctgtc cagtgagttc tggccgccct tcaaggacga gaagctggag gtccccgagg atatcagggc agccctggag gcttactgca agaagtatga gcagctcaag gccatgcgga ccctcagttg gaagcacacc ctgggcctgg tgaccatgga cgtggagctg gccgaccgca cgctgtctgt ggcggtcacc ccagtacagg cggtgatctt gctgtatttt caggaccaag ccagctggac cctggaggaa ctgagcaagg cggtgaagat gcccgtggcg ctgctgcggc ggcggatgtc cgtgtggctg cagcagggtg tgctgcgtga ggagcccccc ggcaccttct ctgtcattga ggaggagcgg cctcaggacc gggacaacat ggtgctcatt gacagtgacg acgagagcga ctccggcatg gcctcccagg ccgaccagaa ggaggaggag ctgctgctct tctggacgta catccaggcc atgctgacca acctggagag cctctcactg gatcgtatct acaacatgct ccgcatgttt gtggtgactg ggcctgcact ggccgagatt gacctgcagg agctgcaggg ctacctgcag aagaaggtgc gggaccagca gctcgtctac tcggccggcg tctaccgcct gcccaagaac Protein function: Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. [The UniProt Consortium]