AKR7A2 (Vector pENTR223.1, Accession No. BC004111)

Length: 993 Sequence: atgtcccggc caccgccacc gcgggtcgcc tcggtgctgg gcaccatgga gatggggcgc cgcatggacg cgcccgccag cgccgcggcc gtgcgcgcct ttctggagcg cggccacacc gaactggaca cggccttcat gtacagcgac ggccagtccg agaccatcct gggcggcctg gggctcgggc tgggcggtgg cgactgcaga gtgaaaattg ccaccaaggc caacccttgg gatggaaaat cactaaagcc tgacagtgtc cggtcccagc tggagacgtc attgaagagg ctgcagtgtc cccaagtgga cctcttctac ctacacgcac ctgaccacgg caccccggtg gaagagacgc tgcatgcctg ccagcggctg caccaggagg gcaagttcgt ggagcttggc ctctccaact atgctagctg ggaagtggcc gagatctgta ccctctgcaa gagcaatggc tggatcctgc ccactgtgta ccagggcatg tacaacgcca ccacccggca ggtggaaacg gagctcttcc cctgcctcag gcactttgga ctgaggttct atgcctacaa ccctctggct gggggcctgc tgactggcaa gtacaagtat gaggacaagg acgggaaaca gcctgtgggc cgcttctttg ggaatagctg ggctgagacc tacaggaatc gcttctggaa ggagcaccac ttcgaggcca ttgcgttggt ggagaaggcc ctgcaggccg catatggcgc cagcgccccc agtgtgacct cggctgccct ccggtggatg taccaccact cacagctgca gggtgcccac ggggacgcgg tcatcctggg catgtccagc ctggagcagc tggagcagaa cttggcagca acagaggaag ggcccctgga gccggctgtc gtggatgcct ttaatcaagc ctggcatttg gttgctcacg aatgtcccaa ctacttccgc Protein function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2- aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10- phenanthrenequinone (in vitro). Can reduce the dialdehyde protein- binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. [The UniProt Consortium]