ACOT8 (Vector pUC, Accession No. BC117155)

Length: 960 Sequence: atgtcgtccc cgcaggcccc agaagatggg cagggctgtg gcgaccgcgg cgatccccct ggggacctcc gtagcgtctt ggtcacgacc gtgctcaacc tcgagccgct ggacgaggat ctcttcagag gaaggcatta ctgggtaccg gccaagaggc tgtttggtgg tcagatcgtg ggccaggccc tggtggctgc agccaagtct gtgagtgaag acgtccacgt gcactccctg cactgctact ttgttcgggc aggggacccg aagctgccag tactgtacca agtggagcgg acacgaacag ggtcgagctt ctcggtgcgc tctgtgaagg ccgtgcaaca tgggaagccc atcttcatct gccaggcctc cttccagcag gcccagccca gccccatgca gcaccagttc tccatgccca ctgtgccacc accagaagag ctgcttgact gtgagaccct cattgaccag tatttaaggg accctaacct ccaaaagagg tacccattgg cgctcaaccg aattgctgct caggaggtcc ccattgagat caagccagta aacccatccc ccctgagcca gctgcagaga atggagccca aacagatgtt ctgggtgcga gcccggggct atattggcga gggcgacatg aagatgcact gctgcgtggc cgcctatatc tccgactatg ccttcttggg cactgcactg ctgcctcacc agtggcagca caaggtgcac ttcatggtct cactggacca ttccatgtgg ttccacgccc ccttccgagc tgaccactgg atgctctatg aatgcgagag cccctgggcc ggtggctctc gggggctggt ccatgggcgg ctgtggcgtc aggatggagt cctagctgtg acctgtgccc aggagggcgt gatccgagtg aagccccagg tctcagagag Protein function: Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9299485, PubMed:9153233). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl- CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). ACOT8 is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431). [The UniProt Consortium]