ACMSD (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 837 Sequence: atgggaaagt cttcagagtg gtgcgagaga attgctggga tccagaagtt cgtattagag aaatggacca aaaaggccaa acctgaggac actttaaacc tgtgccagct tttaaacaac gaccttgcca gcaccgttgt gagctacccc aggaggttcg tgggtctggg gacgttgccc atgcaggccc ctgagctggc ggtcaaggag atggagcgct gtgtgaaaga gctgggcttt cccggggtcc aaattggcac ccacgtcaac gagtgggacc tgaacgcgca ggagctcttt cctgtctatg cggcagccga aaggctgaag tgttccctgt tcgtgcatcc ctgggacatg cagatggatg gacgaatggc caaatactgg ctcccttggc ttgtaggaat gccagcagag accaccatag ccatttgctc catgatcatg ggtggagtat ttgagaagtt tcccaaactg aaagtgtgtt tcgcacatgg tggtggtgcc ttccccttca cagtgggaag aatctcccat ggattcagca tgcgcccaga tctgtgtgcc caggacaacc ccatgaaccc gaagaaatac cttggttcct tttacacaga tgctttggtt catgatcctc tgtccctcaa gctgttaaca gatgtcatag gaaaggataa agtcattttg ggaaccgatt acccctttcc actaggtgag ctggaacctg ggaaactaat agagtccatg gaagaatttg atgaagaaac aaagaataaa ctcaaagccg gcaatgccct ggcatttttg ggtcttgaga gaaaacaatt Protein function: Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. [The UniProt Consortium]