Vitamin K3-d8

Vitamin K3-d8 is intended for use as an internal standard for the quantification of vitamin K3 (Cay-15950) by GC- or LC-MS. Vitamin K3 is a synthetic form of vitamin K. It is an inhibitor of human tissue transglutaminase 2 (TGM2, IC50 = 2.2 µM). Vitamin K3 induces cell death in six neuroblastoma cell lines (IC50s = 3.18-7.09 µM), as well as human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs, IC50s = 6.1 and 18.05, respectively). It decreases proliferation and inhibits migration in a wound healing assay in primary conjunctival fibroblasts when used at concentrations of 2, 4, or 6 mg/L. Vitamin K3 (200 µM) reduces the levels of glutathione (GSH) and increases the levels of glutathione disulfide (GSSG) and oxidized NADPH in isolated rat hepatocytes.Formal Name: 2-methyl-d3-1,4-naphthalenedione-2,5,6,7,8-d5. CAS Number: 478171-80-1. Synonyms: Menadione-d8. Molecular Formula: C11D8O2. Formula Weight: 180.2. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/mL, Ethanol: Sparingly soluble: 1-10 mg/mL. SMILES: O=C1C2=C([2H])C([2H])=C([2H])C([2H])=C2C(C([2H])=C1C([2H])([2H])[2H])=O. InChi Code: InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3/i1D3,2D,3D,4D,5D,6D. InChi Key: MJVAVZPDRWSRRC-JGUCLWPXSA-N.