Thiamethoxam-d3

Thiamethoxam-d3 is intended for use as an internal standard for the quantification of thiamethoxam (Cay-25784) by GC- or LC-MS. Thiamethoxam is a neonicotinoid insecticide and a prodrug form of the neonicotinoid insecticide clothianidin (Cay-29605). It binds to nicotinic acetylcholine receptors (nAChRs) with low affinity (IC50 = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = >3,000 nM). Thiamethoxam induces mortality in a variety of insects, including A. craccivora, M. persicae, and S. littoralis when administered in contact/feeding assays (LC80s = 12, 3, and 3 mg AI/L, respectively) and via systemic administration (LC80s = 0.8, 0.2, and 0.8 mg AI/L, respectively), as well as N. lugens and D. balteata in contact/feeding assays (LC80s = 0.8 mg AI/L for both). Thiamethoxam also induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays when used at a concentration of 200 mg/L. Formulations containing thiamethoxam have been used in the control of insects in agriculture.Formal Name: 3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-(methyl-d3)-N-nitro-4H-1,3,5-oxadiazin-4-imine. CAS Number: 1294048-82-0. Molecular Formula: C8H7ClD3N5O3S. Formula Weight: 294.7. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble. SMILES: O=[N](/N=C1N(COCN\1C([2H])([2H])[2H])CC(S2)=CN=C2Cl)=O. InChi Code: InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3/b11-8-/i1D3. InChi Key: NWWZPOKUUAIXIW-FVFGAQAMSA-N.