JWH 018 N-(5-hydroxypentyl) metabolite-d5

JWH 018 N-(5-hydroxypentyl) metabolite-d5 contains five deuterium atoms at the 2', 4', 5', 6', and 7' positions. It is intended for use as an internal standard for the quantification of JWH 018 N-(5-hydroxypentyl) metabolite by GC- or LC-mass spectrometry (MS). JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06. JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. JWH 018 N-(5-hydroxypentyl) metabolite is a major urinary metabolite of JWH 018, characterized by monohydroxylation of the N-alkyl chain. In urine samples, this metabolite is almost completely glucuronidated.Formal Name: (1-(5-hydroxypentyl)-1H-indol-3-yl)-methanone-2',4',5',6',7'-d5. CAS Number: 2748469-26-1. Molecular Formula: C24H18D5NO2. Formula Weight: 362.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 20 mg/ml, Ethanol: 15 mg/ml. lambdamax: 218, 246, 316 nm. SMILES: O=C(C1=C([2H])N(CCCCCO)C2=C1C([2H])=C([2H])C([2H])=C2[2H])C3=C4C(C=CC=C4)=CC=C3. InChi Code: InChI=1S/C24H23NO2/c26-16-7-1-6-15-25-17-22(20-12-4-5-14-23(20)25)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17,26H,1,6-7,15-16H2/i4D,5D,12D,14D,17D. InChi Key: UGHBAICDASCCIQ-QWWVLHFXSA-N.