Campesterol-d7

Campesterol-d7 is intended for use as an internal standard for the quantification of campesterol (Cay41695) by GC- or LC-MS. Campesterol is a phytosterol that has been found in D. innoxia and has diverse biological activities. It inhibits basic FGF-induced proliferation in, and vessel formation by, human umbilical vein endothelial cells (HUVECs) when used at concentrations of 1, 5, or 10 µM. Campesterol (15 µM) decreases the proliferation of MCF-7 and ZR-75-1 breast cancer cells. It reduces the levels of estrogen receptor alpha (ERalpha) in, and the diameter of, patient-derived breast cancer organoids when used at a concentration of 10 µM. Campesterol has been used as a marker of cholesterol intestinal absorption in humans.. SMILES: C[C@@]12[C@](CC[C@]2([H])[C@@H](CCC(C)C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C. InChi Code: InChI=1S/C28H48O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h9,18-20,22-26,29H,7-8,10-17H2,1-6H3/t19?,20-,22+,23+,24-,25+,26+,27+,28-/m1/s1/i1D3,2D3,18D. InChi Key: SGNBVLSWZMBQTH-IMAWIAHVSA-N