Zafirlukast

Zafirlukast
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10008282-10 10 mg -

6 - 10 business days*

18.00€
Cay10008282-100 100 mg -

6 - 10 business days*

140.00€
Cay10008282-500 500 mg -

6 - 10 business days*

613.00€
Cay10008282-1 1 g -

6 - 10 business days*

1,050.00€
 
Zafirlukast is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 0.014 µM in a... more
Product information "Zafirlukast"
Zafirlukast is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 0.014 µM in a cell-based calcium mobilization assay). It is selective for CysLT1 over CysLT2 receptors (IC50 = 58 µM). It inhibits mucus secretion induced by leukotriene D4 (LTD4, Cay-20310) in isolated guinea pig trachea (IC50 = 0.6 µM). Zafirlukast (5 µM) inhibits ovalbumin-induced increases in tracheal mucus secretion in ovalbumin-sensitized guinea pigs by 65%. It inhibits LTD4-induced bronchoconstriction in anesthetized guinea pigs (ED50 = 61 nmol/kg, i.v.). Formulations containing zafirlukast have been used in the prophylaxis and chronic treatment of asthma. Formal Name: [3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]-carbamic acid, cyclopentyl ester. CAS Number: 107753-78-6. Molecular Formula: C31H33N3O6S. Formula Weight: 575.7. Purity: >97%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): .5 mg/ml, DMSO: 20 mg/ml, Ethanol: .25 mg/ml. lambdamax: 203, 215, 241, 299 nm. SMILES: COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C. InChi Code: InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35). InChi Key: YEEZWCHGZNKEEK-UHFFFAOYSA-N.
Keywords: [3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]-carbamic acid, cyclopentyl ester
Supplier: Cayman Chemical
Supplier-Nr: 10008282

Properties

Application: CysLT1 receptor antagonist
MW: 575.7 D
Formula: C31H33N3O6S
Purity: >97%
Format: Crystalline Solid

Database Information

CAS : 107753-78-6| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
H Phrases: H413
P Phrases: P273, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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