YK-712

An ionizable cationic lipid, has been used in the generation of LNPs for the delivery of mRNA in vitro and in vivo, intramuscular administration of YK-712-containing LNPs encapsulating OVA-encoding mRNA accumulate primarily in the liver in mice, while YK-712-TLR-LNPs accumulate primarily in the spleen, intramuscular administration YK-712-TLR-LNPs encapsulating OVA-encoding mRNA promotes APC maturation, induces T cell activation, and increases IFN-gamma plasma levels in mice, intramuscular administration of YK-712-TLR-LNPs reduces tumor growth and increases survival in a murine model of melanoma using OVA-expressing B16/F10 cells. SMILES: O=C(CCCCCCCN(CCO)CCCCCC1OC(CCCCCCCCCC)OC1)OC(CCCCCCCC)CCCCCCCC. InChi Code: InChI=1S/C45H89NO5/c1-4-7-10-13-16-17-22-29-36-45-49-41-43(51-45)34-27-24-31-38-46(39-40-47)37-30-23-18-21-28-35-44(48)50-42(32-25-19-14-11-8-5-2)33-26-20-15-12-9-6-3/h42-43,45,47H,4-41H2,1-3H3. InChi Key: BZWQIBPYHDAROS-UHFFFAOYSA-N