WHI-P97

WHI-P97 is an inhibitor of JAK3 (IC50 = 11 µM). It inhibits leukotriene C4 (LTC4) and LTB4 release, mediated by the high-affinity IgE receptor Fc epsilon receptor I (FcepsilonRI), from RBL-2H3 mast cells when used at a concentration of 10 µM. It also inhibits FcepsilonRI-mediated 5-lipoxygease (5-LO) translocation to the membrane in RBL-2H3 mast cells. In vivo, WHI-P97 (40 mg/kg) reduces antigen-induced LTC4 production in IgE-sensitized mice. It also reduces airway hyperresponsiveness and bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a mouse model of ovalbumin-induced allergic asthma when administered at doses of 12 and 40 mg/kg.Formal Name: 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol. CAS Number: 211555-05-4. Synonyms: HY-11067. Molecular Formula: C16H13Br2N3O3. Formula Weight: 455.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 3.33 mg/ml. SMILES: COC1=CC2=C(N=CN=C2NC3=CC(Br)=C(C(Br)=C3)O)C=C1OC. InChi Code: InChI=1S/C16H13Br2N3O3/c1-23-13-5-9-12(6-14(13)24-2)19-7-20-16(9)21-8-3-10(17)15(22)11(18)4-8/h3-7,22H,1-2H3,(H,19,20,21). InChi Key: YVCXQRVVNQMZEI-UHFFFAOYSA-N.