Vicenin-2

Vicenin-2 is a polyketide synthase-derived flavonoid glycoside that has been found in C. subternata and has diverse biological activities. It inhibits thrombin-induced aggregation of isolated mouse platelets when used at concentrations ranging from 2 to 30 µM, as well as increases tail bleeding time in mice when administered at a dose of 35.7 µg/animal. Vicenin-2 (1 mg/kg) reduces tumor growth in a PC3 prostate cancer mouse xenograft model. It decreases trabecular separation, as well as increases trabecular thickness and area, in an ovariectomized rat model of osteoporosis. Vicenin-2 (50 mg/kg) decreases ulceration and increases colon weight and length in a mouse model of colitis induced by dextran sulfate (DSS, Cay-23250).Formal Name: 6,8-di-beta-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 23666-13-9. Synonyms: Vicenin II, Violantin. Molecular Formula: C27H30O15. Formula Weight: 594.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: Soluble. lambdamax: 218, 274, 335 nm. SMILES: OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1C2=C3OC(C4=CC=C(O)C=C4)=CC(C3=C(O)C([C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)=C2O)=O. InChi Code: InChI=1S/C27H30O15/c28-6-12-17(32)21(36)23(38)26(41-12)15-19(34)14-10(31)5-11(8-1-3-9(30)4-2-8)40-25(14)16(20(15)35)27-24(39)22(37)18(33)13(7-29)42-27/h1-5,12-13,17-18,21-24,26-30,32-39H,6-7H2/t12-,13-,17-,18-,21+,22+,23-,24-,26+,27+/m1/s1. InChi Key: FIAAVMJLAGNUKW-VQVVXJKKSA-N. Origin: Plant/Desmodium styracifolium.