U-46619 Glycine methyl ester

U-46619 Glycine methyl ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010522-25 25 µg -

6 - 10 business days*

32.00€
Cay10010522-50 50 µg -

6 - 10 business days*

57.00€
Cay10010522-100 100 µg -

6 - 10 business days*

100.00€
 
U-46619 is a stable analog of the endoperoxide PGH2, and a TP receptor agonist. It exhibits... more
Product information "U-46619 Glycine methyl ester"
U-46619 is a stable analog of the endoperoxide PGH2, and a TP receptor agonist. It exhibits properties similar to TXA2, causing platelet shape change, aggregation, and contraction of vascular smooth muscle. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively, and for aggregation, are 82, 145, and 65 nM, respectively. U-46619 glycine methyl ester contains a modification at the C-1 position of U-46619 that may uniquely alter its binding properties to the TP receptor or any of the PGH2-metabolizing enzymes. As a stable PGH2 analog, it could therefore be a useful tool to explore the inhibition of various enzymes in the arachidonic acid metabolic pathway. U-46619 glycine methyl ester may also serve as a lipophilic prodrug form of U-46619 that will alter its distribution and pharmacokinetic properties. There are no published reports on the biological activity of U-46619 glycine methyl ester. Formal Name: 9,11-dideoxy-9alpha,11alpha-methanoepoxy-prosta-5Z,13E-dien-1-oic acid, methyl ester. Molecular Formula: C24H39NO5. Formula Weight: 421.6. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: CCCCCC(O)/C=C/[C@H]1C2OCC(C2)C1C/C=C\CCCC(=O)NCC(=O)OC. InChi Code: InChI=1S/C24H39NO5/c1-3-4-7-10-19(26)13-14-21-20(18-15-22(21)30-17-18)11-8-5-6-9-12-23(27)25-16-24(28)29-2/h5,8,13-14,18-22,26H,3-4,6-7,9-12,15-17H2,1-2H3,(H,25,27)/b8-5-,14-13+/t18-,19+,20-,21-,22-/m1/s1. InChi Key: STIYTIWKJAUJKK-WUXVMKFXSA-N.
Keywords: 9,11-dideoxy-9alpha,11alpha-methanoepoxy-prosta-5Z,13E-dien-1-oic acid, methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 10010522

Properties

Application: Bioactive lipid assays
MW: 421.6 D
Formula: C24H39NO5
Purity: >98%
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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