Typhaneoside

Typhaneoside is a flavonoid glycoside that has been found in T. angustifolia and has diverse biological activities. It decreases colony size and induces ferroptosis and cell cycle arrest at the G2/M phase in Kasumi-1 and NB4 leukemia cells when used at a concentration of 40 µM. Typhaneoside (70 µM) reduces LPS-induced decreases in cell viability, increases in malondialdehyde (MDA) and nitric oxide (NO) levels, and decreases in superoxide dismutase (SOD) activity in human umbilical vein endothelial cells (HUVECs). It limits increases in glutamate secretion and intracellular calcium levels induced by the non-specific voltage-gated potassium channel blocker 4-aminopyridine (Cay-18511) in isolated rat cerebral synaptosomes when used at a concentration of 20 µM. Typhaneoside, in complex with a tetrahedral framework nucleic acid (tFNA), decreases the area and severity of necrotic kidney tissue, the number of apoptotic kidney cells, blood urea nitrogen and serum creatinine levels, and increases mitochondrial membrane integrity in isolated kidney cells in a mouse model of renal ischemia-reperfusion injury induced by bilateral renal pedicle clamping.Formal Name: 3-[(O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1->6)]-beta-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 104472-68-6. Molecular Formula: C34H42O20. Formula Weight: 770.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble, Water: Soluble. SMILES: O=C(C(O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O)O)O[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O)=C(C4=CC(OC)=C(C=C4)O)OC5=CC(O)=C6)C5=C6O. InChi Code: InChI=1S/C34H42O20/c1-10-20(38)24(42)27(45)32(49-10)48-9-18-22(40)26(44)31(54-33-28(46)25(43)21(39)11(2)50-33)34(52-18)53-30-23(41)19-15(37)7-13(35)8-17(19)51-29(30)12-4-5-14(36)16(6-12)47-3/h4-8,10-11,18,20-22,24-28,31-40,42-46H,9H2,1-3H3/t10-,11-,18+,20-,21-,22+,24+,25+,26-,27+,28+,31+,32+,33-,34-/m0/s1. InChi Key: POMAQDQEVHXLGT-QDYYQVSOSA-N. Origin: Plant/Typha orientalis Presl.