Trehalose 6,6'-Dibehenate

Trehalose 6,6'-dibehenate (TDB) is a synthetic glycolipid and derivative of trehalose-6,6' dimycolate (TDM), also known as mycobacterial cord factor. It binds to a fusion protein of mouse macrophage-inducible C-type lectin (Mincle) and human IgG1 Fc in a cell-free assay when used at a concentration of 10 µg/ml. TDB (5 µg/ml) induces nitric oxide (NO) and G-CSF production in mouse bone marrow macrophages in a Mincle-dependent manner. Liposomes containing TDB and dimethyldioctadecylammonium (DDA, Cay-26120) as adjuvants and the mycobacterial lipid antigens diacylated sulfoglycolipid (Ac2SGL) and phosphatidyl-myo-inositol dimannoside (PIM2) decrease spleen bacterial load and the number of lung and spleen lesions in a guinea pig model of M. tuberculosis infection.Formal Name: 6-docosanoate 6-O-(1-oxodocosyl)-alpha-D-glucopyranosyl alpha-D-glucopyranoside. CAS Number: 66758-35-8. Synonyms: TDB, Trehalose Dibehenate, 22:0 Trehalose. Molecular Formula: C56H106O13. Formula Weight: 987.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly Soluble, DMSO: Slightly Soluble. SMILES: O[C@H]([C@H]1O)[C@H](O[C@@H]([C@H]1O)COC(CCCCCCCCCCCCCCCCCCCCC)=O)O[C@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)COC(CCCCCCCCCCCCCCCCCCCCC)=O. InChi Code: InChI=1S/C56H106O13/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39-41-47(57)65-43-45-49(59)51(61)53(63)55(67-45)69-56-54(64)52(62)50(60)46(68-56)44-66-48(58)42-40-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h45-46,49-56,59-64H,3-44H2,1-2H3/t45-,46-,49-,50-,51+,52+,53-,54-,55-,56-/m1/s1. InChi Key: ZLJJDBSDZSZVTF-LXOQPCSCSA-N.