Telocinobufagin

Telocinobufagin is a cardiotonic steroid that has been found in skin secretions of the toad B. rubescens and has diverse biological activities. It inhibits human kidney Na+/K+-ATPase with an IC50 value of 44.2 nM. Telocinobufagin (9.9 µg/ml) increases contraction force in isolated frog ventricle strips by 30.2%. It is cytotoxic to HL-60, HCT8, SF295, MDA-MB-435 cancer cells and human peripheral blood lymphocytes (IC50s = 0.06, 0.06, 0.03, 0.11, and 0.05 µM, respectively). Telocinobufagin is also active against E. coli and S. aureus (MICs = 64 and 128 µg/ml, respectively).Formal Name: 3beta,5beta,14-trihydroxy-bufa-20,22-dienolide. CAS Number: 472-26-4. Synonyms: NSC 90782, NSC 119989, Telobufotoxin, Telocinobufogenin. Molecular Formula: C24H34O5. Formula Weight: 402.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: slightly, heated, Methanol: slightly soluble. lambdamax: 301 nm. SMILES: O[C@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@]3(O)CC[C@@H]4C5=COC(C=C5)=O)(O)C1. InChi Code: InChI=1S/C24H34O5/c1-21-9-5-16(25)13-23(21,27)11-7-19-18(21)6-10-22(2)17(8-12-24(19,22)28)15-3-4-20(26)29-14-15/h3-4,14,16-19,25,27-28H,5-13H2,1-2H3/t16-,17+,18-,19+,21+,22+,23-,24-/m0/s1. InChi Key: PBSOJKPTQWWJJD-ZBDZJSKLSA-N.