Tauroursodeoxycholic Acid-d4 (sodium salt)

Tauroursodeoxycholic acid-d4 (TUDCA-d4) is intended for use as an internal standard for the quantification of tauroursodeoxycholic acid (Cay-20277, Cay-9003379) by GC- or LC-MS. TUDCA is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid (Cay-15121). TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears. It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.Formal Name: 2-[[(3alpha,5beta,7beta)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt. CAS Number: 2410279-95-5. Synonyms: 3alpha,7beta-dihydroxy-5beta-cholanoyl Taurine-d4, Sodium Tauroursodeoxycholate-d4, TUDCA-d4, UR-906-d4. Molecular Formula: C26H40D4NO6S . Na. Formula Weight: 525.7. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: C[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]. InChi Code: InChI=1S/C26H45NO6S.Na/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29,/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33),/q,+1/p-1/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-,/m1./s1/i8D2,14D2,. InChi Key: IYPNVUSIMGAJFC-OICBMEOSSA-M.