Taurohyodeoxycholic Acid (sodium salt)

Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid (Cay-20294). THDCA decreases the size and weight of human gallstones in vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats. Co-administration of THDCA with taurochenodeoxycholic acid (TCDCA, Cay-20275) prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats. THDCA also reduces myeloperoxidase activity, expression of TNF-alpha and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis.Formal Name: 2-[[(3alpha,5beta,6alpha)-3,6-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt. CAS Number: 38411-85-7. Synonyms: Taurine Hyodeoxycholate, THDCA. Molecular Formula: C26H44NO6S . Na. Formula Weight: 521.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. SMILES: C[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]. InChi Code: InChI=1S/C26H45NO6S.Na/c1-16(4-7-24(30)27-12-13-34(31,32)33)19-5-6-20-18-15-23(29)22-14-17(28)8-10-26(22,3)21(18)9-11-25(19,20)2,/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33),/q,+1/p-1/t16-,17-,18+,19-,20+,21+,22+,23+,25-,26-,/m1./s1. InChi Key: VNQXUJQHLHHTRC-WMWRQJSFSA-M.