Taurodeoxycholic Acid-d4 (sodium salt)

Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid (Cay-15935) by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid (Cay-20756, Cay-18231). Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally. Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.Formal Name: 2-[[(3alpha,5beta,12alpha)-3,12-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt. CAS Number: 2410279-82-0. Synonyms: Sodium Taurodeoxycholate-d4, TDCA-d4. Molecular Formula: C26H40D4NO6S . Na. Formula Weight: 525.7. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: [H][C@]12[C@@]([C@@](CC[C@]3([H])[C@H](C)CCC(NCCS(=O)([O-])=O)=O)([H])[C@]3(C)[C@@H](O)C2)([H])CC[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@@]41C.[Na+]. InChi Code: InChI=1S/C26H45NO6S.Na/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3,/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33),/q,+1/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-,/m1./s1/i10D2,14D2,. InChi Key: YXHRQQJFKOHLAP-YPYHFUETSA-M.