Swertisin

Swertisin is a flavonoid C-glycoside that has been found in Swertia japonica and has diverse biological activities. It inhibits sodium-glucose cotransporter 2 (SGLT2) in HEK293 cells when used at a concentration of 7.5 µg/ml and is an adenosine A1 receptor antagonist (IC50 = 137 µM). Swertisin (0.2-5 µM) inhibits hepatitis B virus (HBV) replication in HepG2 2.2.15 cells. It decreases blood glucose levels in a mouse model of diabetes induced by streptozotocin (Cay-13104), as well as prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.Formal Name: 6-beta-D-glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one. CAS Number: 6991-10-2. Synonyms: NSC 641547. Molecular Formula: C22H22O10. Formula Weight: 446.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 216, 243, 276, 342 nm. SMILES: OC1=C2C(OC(C3=CC=C(C=C3)O)=CC2=O)=CC(OC)=C1[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO)O)O. InChi Code: InChI=1S/C22H22O10/c1-30-13-7-14-16(11(25)6-12(31-14)9-2-4-10(24)5-3-9)19(27)17(13)22-21(29)20(28)18(26)15(8-23)32-22/h2-7,15,18,20-24,26-29H,8H2,1H3/t15-,18-,20+,21-,22+/m1/s1. InChi Key: ABRULANJVVJLFI-DGHBBABESA-N. Origin: Plant/Swertia bimaculata.