(-)-Sweroside

(-)-Sweroside is an iridoid glycoside that has been found in L. japonica and has diverse biological activities, including anti-inflammatory, antiproliferative, and anti-obesity properties. It inhibits LPS-induced production of prostaglandin E2 (PGE2, Cay-14010) and reactive oxygen species (ROS) in mouse RAW 264.7 macrophages when used at a concentration of 40 µM. (-)-Sweroside inhibits the growth of U937 lymphoma and HL-60 leukemia cells (IC50s = 67.92 and 62.58 µM, respectively) but not non-cancerous human peripheral blood mononuclear cells (PBMCs) or mouse bone marrow cells (BMCs). It reduces tumor growth in an HL-60 mouse xenograft model when administered at a dose of 50 mg/kg. (-)-Sweroside (120 mg/kg) reduces weight gain and serum total cholesterol, triglyceride, LDL cholesterol (LDL-C), and free fatty acid (FFA) levels in a mouse model of obesity induced by a high-fat diet (HFD).Formal Name: (4aS,5R,6S)-5-ethenyl-6-(beta-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one. CAS Number: 14215-86-2. Synonyms: 1,9-trans-9,5-cis-Sweroside. Molecular Formula: C16H22O9. Formula Weight: 358.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 244 nm. SMILES: C=C[C@@H]1[C@@]2([H])C(C(OCC2)=O)=CO[C@H]1O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO. InChi Code: InChI=1S/C16H22O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2,6-8,10-13,15-20H,1,3-5H2/t7-,8+,10-,11-,12+,13-,15+,16+/m1/s1. InChi Key: VSJGJMKGNMDJCI-ZASXJUAOSA-N. Origin: Plant/Swertia bimaculata.