SH-42

SH-42 is an inhibitor of ?24-dehydrocholesterol reductase (DHCR24, IC50 = 4.2 nM). It increases serum levels of desmosterol (24-dehydro cholesterol, Cay-14943), the immediate precursor of cholesterol (Cay-9003100) in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) and its metabolite prostaglandin E2 (PGE2, Cay-14010), as well as docosahexaenoic acid (Cay-90310) and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A (Cay-21175). SH-42 (0.5 mg/animal three times per week) decreases disease severity in mice expressing liver X receptor alpha (LXRalpha-positive) but not LXRalpha-deficient mice in a model of hepatic steatosis induced by a high-fat high-cholesterol diet.Formal Name: (3beta,5alpha,20S)-3-acetate 21-formate, 20-methyl-pregn-7-ene-3,21-diol. CAS Number: 2143952-36-5. Molecular Formula: C25H38O4. Formula Weight: 402.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 10 mg/ml. SMILES: C[C@@]12[C@]3([H])C([C@@]4([H])[C@](CC3)([C@]([C@@H](COC=O)C)([H])CC4)C)=CC[C@@]1([H])C[C@H](CC2)OC(C)=O. InChi Code: InChI=1S/C25H38O4/c1-16(14-28-15-26)21-7-8-22-20-6-5-18-13-19(29-17(2)27)9-11-24(18,3)23(20)10-12-25(21,22)4/h6,15-16,18-19,21-23H,5,7-14H2,1-4H3/t16-,18+,19+,21-,22+,23+,24+,25-/m1/s1. InChi Key: ZMSGAXSBKXUQKY-PUCUFLQQSA-N.