SEW2871

SEW2871
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10006440-5 5 mg -

approx. 1-3 business days

32.00€
Cay10006440-10 10 mg -

6 - 10 business days*

60.00€
Cay10006440-25 25 mg -

6 - 10 business days*

142.00€
Cay10006440-50 50 mg -

6 - 10 business days*

267.00€
 
Sphingosine-1-phosphate receptor 1 (S1P1) is one of five high affinity G protein-coupled S1P... more
Product information "SEW2871"
Sphingosine-1-phosphate receptor 1 (S1P1) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood. Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P3, the receptor responsible for regulation of heart rate. SEW2871 is a selective S1P1 receptor agonist in both human and mouse that is not active at the S1P2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia. Formal Name: 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole. CAS Number: 256414-75-2. Molecular Formula: C20H10F6N2OS. Formula Weight: 440.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): .5 mg/ml, DMSO: 2 mg/ml, Ethanol: 5 mg/ml. lambdamax: 242, 273 nm. SMILES: FC(F)(F)c1cccc(c1)c1noc(n1)c1cc(c2ccccc2)c(s1)C(F)(F)F. InChi Code: InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H. InChi Key: OYMNPJXKQVTQTR-UHFFFAOYSA-N.
Keywords: 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
Supplier: Cayman Chemical
Supplier-Nr: 10006440

Properties

Application: S1P1 receptor agonist
MW: 440.4 D
Formula: C20H10F6N2OS
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 256414-75-2| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H300
P Phrases: P264, P270, P301+310, P321, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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