SC-58125

SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2. When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1. In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 of 70 nM. It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.Formal Name: 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole. CAS Number: 162054-19-5. Molecular Formula: C17H12F4N2O2S. Formula Weight: 384.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (1:3): 250 µg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 255 nm. SMILES: FC(C=C1)=CC=C1C2=CC(C(F)(F)F)=NN2C3=CC=C(S(=O)(C)=O)C=C3. InChi Code: InChI=1S/C17H12F4N2O2S/c1-26(24,25)14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3. InChi Key: JHBIMJKLBUMNAU-UHFFFAOYSA-N.