Rosuvastatin lactone

Rosuvastatin lactone is the lactone form of the HMG-CoA reductase inhibitor rosuvastatin (Cay-12029, Cay-18813). It is found in vivo following rosuvastatin administration. Rosuvastatin lactone is an inhibitor of the cytochrome P450 (CYP) isoforms CYP2C9.1 and CYP2C9.3 (IC50s = 8.52 and 4.1 µM, respectively).Formal Name: N-[4-(4-fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methyl-methanesulfonamide. CAS Number: 503610-43-3. Synonyms: (+)-Rosuvastatin lactone, Rosuvastatin-5S-lactone, RSTL. Molecular Formula: C22H26FN3O5S. Formula Weight: 463.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 15 mg/ml, Ethanol: Slightly soluble. lambdamax: 245 nm. SMILES: O[C@@H](CC(O1)=O)C[C@H]1/C=C/C2=C(C(C)C)N=C(N(C)S(C)(=O)=O)N=C2C3=CC=C(C=C3)F. InChi Code: InChI=1S/C22H26FN3O5S/c1-13(2)20-18(10-9-17-11-16(27)12-19(28)31-17)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)32(4,29)30/h5-10,13,16-17,27H,11-12H2,1-4H3/b10-9+/t16-,17-/m1/s1. InChi Key: SOEGVMSNJOCVHT-VEUZHWNKSA-N.