RM 133-3

RM 133-3 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing RM 133-3 and encapsulating mRNA encoding human erythropoietin (EPO) increase serum human EPO protein levels in mice.Formal Name: (9Z,9'Z)-((3,3'-((3-(diethylamino)propyl)azanediyl)bis(propanoyl))bis(oxy))bis(octadec-9-ene-18,7-diyl) (5Z,5'Z,8Z,8'Z,11Z,11'Z,14Z,14'Z,17Z,17'Z)-bis(icosa-5,8,11,14,17-pentaenoate). CAS Number: 2941228-90-4. Molecular Formula: C89H150N2O8. Formula Weight: 1376.2. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 25 mg/ml. SMILES: CCN(CC)CCCN(CCC(OCCCCCCCC/C=C\CC(CCCCCC)OC(CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)=O)CCC(OCCCCCCCC/C=C\CC(CCCCCC)OC(CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)=O. InChi Code: InChI=1S/C89H150N2O8/c1-7-13-17-21-23-25-27-29-31-33-35-37-39-45-51-57-65-74-88(94)98-84(70-61-19-15-9-3)72-63-55-49-43-41-47-53-59-67-82-96-86(92)76-80-91(79-69-78-90(11-5)12-6)81-77-87(93)97-83-68-60-54-48-42-44-50-56-64-73-85(71-62-20-16-10-4)99-89(95)75-66-58-52-46-40-38-36-34-32-30-28-26-24-22-18-14-8-2/h13-14,17-18,23-26,29-32,35-38,45-46,51-52,55-56,63-64,84-85H,7-12,15-16,19-22,27-28,33-34,39-44,47-50,53-54,57-62,65-83H2,1-6H3/b17-13-,18-14-,25-23-,26-24-,31-29-,32-30-,37-35-,38-36-,51-45-,52-46-,63-55-,64-56-. InChi Key: XSQVIMUGWPVECK-QEAPGHMNSA-N.