Quercetin-7-O-beta-D-Glucopyranoside

Quercetin-7-O-beta-D-glucopyranoside is a flavonoid originally isolated from G. hirsutum that has diverse biological activities, including antioxidant, anti-inflammatory, and anti-angiogenic properties. It has antioxidant activity in a oxygen radical absorbance capacity (ORAC) assay and decreases tert-butyl hydroperoxide-induced reactive oxygen species (ROS) production in L-929 cells when used at concentrations of 0.25 and 1 µg/ml. Quercetin-7-O-beta-D-glucopyranoside (15 and 30 µg/ml) reduces protein levels of inducible nitric oxide synthase (iNOS) and COX-2 in LPS-stimulated RAW 264.7 cells. It decreases angiogenesis in isolated rat aortic rings and proliferation of human umbilical vein endothelial cells (HUVECs) but has no effect on tube formation or chemotaxis of HUVECs when used at a concentration of 100 µM.Formal Name: 2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-3,5-dihydroxy-4H-1-benzopyran-4-one. CAS Number: 491-50-9. Synonyms: Quercetin 7-Glucoside, Quercimeritrin, Quercimeritroside. Molecular Formula: C21H20O12. Formula Weight: 464.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 256, 372 nm. SMILES: O[C@H]1[C@H](OC2=CC(O)=C(C(C(O)=C(C3=CC(O)=C(O)C=C3)O4)=O)C4=C2)O[C@H](CO)[C@@H](O)[C@@H]1O. InChi Code: InChI=1S/C21H20O12/c22-6-13-15(26)17(28)19(30)21(33-13)31-8-4-11(25)14-12(5-8)32-20(18(29)16(14)27)7-1-2-9(23)10(24)3-7/h1-5,13,15,17,19,21-26,28-30H,6H2/t13-,15-,17+,19-,21-/m1/s1. InChi Key: BBFYUPYFXSSMNV-HMGRVEAOSA-N. Origin: Plant/Sophora japonica L..