PTIQ

PTIQ is a neuroprotective compound. It inhibits tetrahydro-L-biopterin-induced cytotoxicity and increases in matrix metalloproteinase-3 (MMP-3) levels in CATH.a cells (IC50s = 1.8 and 0.06 µM, respectively). PTIQ inhibits LPS-induced production of MMP-3, TNF-alpha, and COX-2 in BV-2 microglia (IC50s = 2.4, 6.5, and 9.3 µM, respectively). In vivo, PTIQ (3 and 30 mg/kg) increases survival of striatal nigral dopaminergic neurons, reduces microglial activation, and alleviates motor deficits in a mouse model of MPTP-induced Parkinson's disease.Formal Name: 1-(3,4-dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone. CAS Number: 1032822-42-6. Molecular Formula: C13H17NO3. Formula Weight: 235.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O=C(CC)N1CC2=CC(O)=C(C=C2CC1)OC. InChi Code: InChI=1S/C13H17NO3/c1-3-13(16)14-5-4-9-7-12(17-2)11(15)6-10(9)8-14/h6-7,15H,3-5,8H2,1-2H3. InChi Key: BEDYMEDICHGLSE-UHFFFAOYSA-N.