PtdIns-(4,5)-P2 (1,2-dioctanoyl) (sodium salt)

The phosphatidylinositol (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns is phosphorylated to mono- (PtdIns-P, PIP), di- (PtdIns-P2, PIP2) and triphosphates (PtdIns-P3, PIP3). Hydrolysis of PIP2 by PI-specific phospholipase C generates IP3 and diacylglycerol (DAG). The DAG and IP3 produced by this reaction are part of a complex biochemical and signal transduction cascade that is at the frontier of scientific research today.Formal Name: 1-(1,2R-dioctanoylphosphatidyl)inositol-4,5-bisphosphate, trisodium salt. Synonyms: DOPI-4,5-P2, Phosphatidylinositol-4,5-bisphosphate C-8, PIP2[4',5'](8:0/8:0), PI(4,5)P2 (8:0/8:0). Molecular Formula: C25H46O19P3 . 3Na. Formula Weight: 812.5. Purity: >97%. Formulation: (Request formulation change), A lyophilized powder. Solubility: CHCl3:CH3OH:H2O (3:2:1): 10 mg/ml, PBS (pH 7.2): Freely soluble. SMILES: O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](O)[C@H]1OP([O-])(OC[C@@H](COC(CCCCCCC)=O)OC(CCCCCCC)=O)=O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C25H49O19P3.3Na/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36,,,/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36),,,/q,3*+1/p-3/t17-,2. InChi Key: WIFRKINRFJNHBB-JJMOSTGOSA-K. Side Chain Carbon Sum: 16:0.