PtdIns-(3,4,5)-P3-biotin (sodium salt)

The PtdIn phosphates play an important role in the generation and transduction of intracellular signals. PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins. Formal Name: 1-((1-octanoyl-N'-biotinoyl-1,6-diaminohexane-2R-octanoyl)phosphatidyl)inositol-3,4,5-triphosphate,tetrasodium salt. CAS Number: 1415684-80-8. Synonyms: Phosphatidylinositol-3,4,5-triphosphate C-8-biotin, PIP3-biotin. Molecular Formula: C35H61N3O24P4S . 4Na. Formula Weight: 1155.8. Purity: >98%. Formulation: A lyophilized powder. Solubility: H2O: 1 mg/ml. SMILES: O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(OC[C@@H](COC(CCCCCCCNC(CCCC[C@@H]2SC[C@@](N3[H])([H])[C@]2([H])N([H])C3=O)=O)=O)OC(CCCCCCC)=O)=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C35H65N3O24P4S.4Na/c1-2-3-4-6-10-17-27(41)58-22(19-56-26(40)16-9-7-5-8-13-18-36-25(39)15-12-11-14-24-28-23(21-67-24)37-35(44)38-28)20-57-66(54,55)62-31-29(42)32(59-63(45,46)47)34(61-65(51,52)53)33(30(31)43)60-64(48,49)50,,,,/h22-24,28-34,42-. InChi Key: IIJJVXPPNNJTJF-HXACWPDNSA-J.