PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin alpha and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and . Formal Name: D-myo-inositol 1-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl hydrogen phosphate] 3,4,5-tris(dihydrogen phosphate), tetrasodium salt. CAS Number: 1628353-02-5. Synonyms: DPPI-3,4,5-P3, Phosphatidylinositol-3,4,5-triphosphate C-16. Molecular Formula: C41H78O22P4 . 4Na. Formula Weight: 1138.9. Purity: >98%. Formulation: A lyophilized powder. Solubility: CHCl3:CH3OH:H2O (2.5:3:1): 3.8 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: [O-]P(OC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)(O[C@@H]1[C@H](O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@H]1O)=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C41H82O22P4.4Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)57-31-33(59-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-58-67(55,56)63-38-36(44)39(60-64(46,47)48)41(62-66(52,53)54)40(37(38)45)61-65(49,50)51,,,,/h33,36-41,44-45H,3-32H2,1. InChi Key: OKHWJEMVEFYEGE-GMPYYQOPSA-J. Side Chain Carbon Sum: 32:0.