PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10008390-100 100 µg -

6 - 10 business days*

50.00€
Cay10008390-500 500 µg -

6 - 10 business days*

225.00€
Cay10008390-1 1 mg -

6 - 10 business days*

400.00€
 
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane... more
Product information "PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)"
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking. PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) is a synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP3, including higher solubility in aqueous media. Formal Name: 1-(1,2R-dihexanoylphosphatidyl)inositol-3,4,5-triphosphate, tetraammonium salt. CAS Number: 799268-62-5. Synonyms: DHPI-3,4,5-P3, Phosphatidylinositol-3,4,5-triphosphate C-6, PIP3C-16. Molecular Formula: C21H54N4O22P4 . 4NH4. Formula Weight: 838.6. Purity: >98%. Formulation: A lyophilized powder. Solubility: Water: 10 mg/ml. SMILES: O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(OC[C@H](OC(CCCCC)=O)COC(CCCCC)=O)=O. InChi Code: InChI=1S/C21H42O22P4/c1-3-5-7-9-14(22)37-11-13(39-15(23)10-8-6-4-2)12-38-47(35,36)43-18-16(24)19(40-44(26,27)28)21(42-46(32,33)34)20(17(18)25)41-45(29,30)31/h13,16-21,24-25H,3-12H2,1-2H3,(H,35,36)(H2,26,27,28)(H2,29,30,31)(H2,32,33,34)/p-4/t13-,16+,1. InChi Key: OTVQICSZDVCXQJ-PKNPMILWSA-J. Side Chain Carbon Sum: 12:0.
Keywords: DHPI-3,4,5-P3, Phosphatidylinositol-3,4,5-triphosphate C-6, PIP3C-16, 1-(1,2R-dihexanoylphosphatidyl)inositol-3,4,5-triphosphate, tetraammonium salt
Supplier: Cayman Chemical
Supplier-Nr: 10008390

Properties

Application: Bioactive lipid assays
MW: 838.6 D
Formula: C21H54N4O22P4 . 4NH4
Purity: >98%
Format: Solid

Database Information

CAS : 799268-62-5| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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