Prostaglandin E1

Prostaglandin E1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13010-1 1 mg -

6 - 10 business days*

30.00€
Cay13010-5 5 mg -

6 - 10 business days*

119.00€
Cay13010-10 10 mg -

6 - 10 business days*

171.00€
Cay13010-50 50 mg -

6 - 10 business days*

764.00€
 
Prostaglandin E1 (PGE1) is a vasoactive prostaglandin and an active metabolite of... more
Product information "Prostaglandin E1"
Prostaglandin E1 (PGE1) is a vasoactive prostaglandin and an active metabolite of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is formed from DGLA by COX-1 and COX-2. PGE1 is an agonist of the PGE2 (Cay-14010) receptor subtypes EP1, EP2, EP3, and EP4, and the IP receptor (Kis = 36, 10, 1.1, 2.1, and 33 nM, respectively, for the mouse receptors). It inhibits ADP-induced platelet aggregation of isolated human platelet-rich plasma (IC50 = 40 nM) and isoproterenol-induced increases in L-type calcium current (ICa) in isolated rabbit atrial cells (EC50 = 27 nM). PGE1 (100 nM) induces vasodilation in isolated rat aortic rings and activates ATP-sensitive potassium channels (KATP) in a cell-attached patch clamp assay using isolated rat vascular smooth muscle cells (VSMCs). It decreases femoral arterial perfusion pressure in dogs. Formulations containing PGE1 have been used in the treatment of erectile dysfunction and to maintain patency of the ductus arteriosus in neonates with congenital heart defects who depend on a patent ductus arteriosus for survival.Formal Name: 11alpha,15S-dihydroxy-9-oxo-prost-13E-en-1-oic acid. CAS Number: 745-65-3. Synonyms: Alprostadil, NSC 165559, PGE1. Molecular Formula: C20H34O5. Formula Weight: 354.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 100 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1. InChi Key: GMVPRGQOIOIIMI-DWKJAMRDSA-N.
Keywords: Alprostadil, PGE1, 9-oxo-11alpha,15S-dihydroxy-prost-13E-en-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 13010

Properties

Application: Bioactive lipid assays
MW: 354.5 D
Formula: C20H34O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 745-65-3| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H360
P Phrases: P201, P202, P264, P270, P280, P330, P301+P310, P308+P313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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