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Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large... more
Product information "Prostaglandin D2"
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as beta-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 µM. Formal Name: 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid. CAS Number: 41598-07-6. Synonyms: PGD2. Molecular Formula: C20H32O5. Formula Weight: 352.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: >100 mg/ml, DMSO: >50 mg/ml, Ethanol: >75 mg/ml, PBS pH 7.2: >5 mg/ml. SMILES: CCCCCC(O)/C=C/[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1. InChi Key: BHMBVRSPMRCCGG-OUTUXVNYSA-N.
Keywords: | PGD2, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 12010 |
Properties
Application: | Bioactive lipid assays |
MW: | 352.5 D |
Formula: | C20H32O5 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 41598-07-6| Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: | ![]() ![]() |
H Phrases: | H302, H360 |
P Phrases: | P201, P202, P264, P270, P280, P301+310, P308+313, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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