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Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells, certain macrophages, and... more
Product information "Prostaglandin D2-biotin"
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells, certain macrophages, and is the predominant PG in the cerebral spinal fluid. PGD2 inhibits platelet aggregation, induces sleep, causes flushing, vasodilation and nasal congestion, and immune modulation, acting through at least two 7-transmembrane G protein-coupled receptors, DP1 and DP2 (CRTH2). PGD2-biotin is an affinity probe which allows PGD2 to be detected through an interaction with the biotin ligand. It was designed to allow PGD2 to be detected in complexes with transmembrane receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of PGs. Formal Name: 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oyl-N'-biotinoyl-1,5-diaminopentane. Synonyms: PGD2-biotin. Molecular Formula: C36H60N4O6S. Formula Weight: 677.0. Purity: >95%. Formulation: A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): .1 mg/ml. SMILES: O=C1C[C@H](O)[C@H](C/C=C\CCCCC(NCCCCCNC(CCCC[C@@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O)[C@H]1/C=C/[C@@H](O)CCCCC. InChi Code: InChI=1S/C36H60N4O6S/c1-2-3-8-15-26(41)20-21-28-27(30(42)24-31(28)43)16-9-5-4-6-10-18-33(44)37-22-13-7-14-23-38-34(45)19-12-11-17-32-35-29(25-47-32)39-36(46)40-35/h5,9,20-21,26-30,32,35,41-42H,2-4,6-8,10-19,22-25H2,1H3,(H,37,44)(H,38,45)(H2,39,40,46). InChi Key: OIOFLLOCLYRSFU-WDPYDZKRSA-N.
Keywords: | PGD2-biotin, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oyl-N'-biotinoyl-1,5-diaminopentane |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10006697 |
Properties
Application: | Affinity probe |
MW: | 677 D |
Formula: | C36H60N4O6S |
Purity: | >95% |
Format: | Solution |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: | ![]() |
H Phrases: | H225 |
P Phrases: | P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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