Plantamajoside

Plantamajoside is a phenylethanoid that has been found in P. lanceolata and has diverse biological activities, including antioxidative, anticancer, and anti-inflammatory properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in a cell-free assay (IC50 = 11.8 µM). It also inhibits 5-lipoxygenase (5-LO) and 15-LO (IC50s = 0.375 and 96 µM, respectively). Plantamajoside decreases viability of TE-1 esophageal squamous cell carcinoma (ESCC) cells when used at concentrations ranging from 20 to 320 µg/ml, as well as inhibits LPS-induced epithelial-to-mesenchymal transition (EMT) in Eca-109 and TE-1 cells and decreases phosphorylated NF-kappaB levels in TE-1 cells. Plantamajoside (3 mg/ear) inhibits mouse ear edema induced by arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) by 25%.Formal Name: 2-(3,4-dihydroxyphenyl)ethyl 3-O-beta-D-glucopyranosyl-beta-D-glucopyranoside 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]. CAS Number: 104777-68-6. Molecular Formula: C29H36O16. Formula Weight: 640.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 33 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 221, 334 nm. SMILES: OC1=C(O)C=CC(CCO[C@@H]2O[C@H](CO)[C@@H](OC(/C=C/C3=CC(O)=C(O)C=C3)=O)[C@H](O[C@@]4([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@H]2O)=C1. InChi Code: InChI=1S/C29H36O16/c30-11-19-22(37)23(38)24(39)29(42-19)45-27-25(40)28(41-8-7-14-2-5-16(33)18(35)10-14)43-20(12-31)26(27)44-21(36)6-3-13-1-4-15(32)17(34)9-13/h1-6,9-10,19-20,22-35,37-40H,7-8,11-12H2/b6-3+/t19-,20-,22-,23+,24-,25-,26-,27-,28-,29+/m1/s1. InChi Key: KFEFLPDKISUVNR-QJEHNBJNSA-N. Origin: Plant/Plantago asiatica L..