PGPC

PGPC
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10044-500 500 µg -

6 - 10 business days*

23.00€
Cay10044-1 1 mg -

6 - 10 business days*

43.00€
Cay10044-5 5 mg -

6 - 10 business days*

180.00€
Cay10044-10 10 mg -

6 - 10 business days*

315.00€
 
PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress. It is... more
Product information "PGPC"
PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress. It is found as a component in mildly oxidized LDL (MM-LDL) and in products formed from the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox-PAPC). PGPC activates peroxisome proliferator-activated receptor (PPARalpha) in a concentration-dependent manner in a cell-based ligand-binding assay. It increases VCAM1 and E-selectin expression in human aortic endothelial cells (HAECs), as well as HAEC binding by monocytes and polymorphonuclear neutrophils (PMNs), in a concentration-dependent manner. PGPC (37.5 µM) also increases total 5-lipoxygenase metabolites in murine resident peritoneal macrophages (RPMs) and induces apoptosis in A7r5 rat aortic smooth muscle cells in vitro when used at a concentration of 50 µM. PGPC levels are increased in the serum, LDL, and peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease. UVA irradiation increases PGPC levels in cultured human skin fibroblasts. Formal Name: 1-palmitoyl-2-glutaryl phosphatidylcholine. CAS Number: 89947-79-5. Synonyms: 1-Hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine, 1-Palmitoyl-2-glutaryl phosphatidylcholine, 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine. Molecular Formula: C29H56NO10P. Formula Weight: 609.7. Purity: >98%. Formulation: A solution in ethanol. Solubility: DMSO: 1 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)OC(=O)CCCC(=O)O. InChi Code: InChI=1S/C29H56NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(33)37-24-26(40-29(34)21-18-19-27(31)32)25-39-41(35,36)38-23-22-30(2,3)4/h26H,5-25H2,1-4H3,(H-,31,32,35,36)/t26-/m1/s1. InChi Key: CDZVJFRXJAUXPP-AREMUKBSSA-N. Side Chain Carbon Sum: 21:0.
Keywords: 1-Hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine, 1-Palmitoyl-2-glutaryl phosphatidylcholine, 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-glutaryl phosphatidylcholine
Supplier: Cayman Chemical
Supplier-Nr: 10044

Properties

Application: Oxidized phospholipid
MW: 609.7 D
Formula: C29H56NO10P
Purity: >98%
Format: Solution

Database Information

CAS : 89947-79-5| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319
P Phrases: P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P305+351+338, P337+313, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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