Parecoxib (sodium salt)

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib (Cay-10006120). It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 µM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).Formal Name: N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-propanamide, monosodium salt. CAS Number: 198470-85-8. Synonyms: SC-69124A. Molecular Formula: C19H17N2O4S . Na. Formula Weight: 392.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 15mg/mL, Ethanol: 3mg/mL, PBS (pH 7.2): 5mg/mL. lambdamax: 245 nm. SMILES: O=S(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)([N-]C(CC)=O)=O.[Na+]. InChi Code: InChI=1S/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15,/h4-12H,3H2,1-2H3,(H,21,22),/q,+1/p-1. InChi Key: HQPVVKXJNZEAFW-UHFFFAOYSA-M.