PAMAM Dendrimer G4.0 Amidoethanol (water solution)

PAMAM dendrimer G4.0 amidoethanol (PAMAM G4.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini that has been used as a drug delivery system in vivo. It is approximately 45 Å in diameter and has 64 surface groups. Conjugates of PAMAM G4.0 amidoethanol and the synthetic glucocorticoid methylprednisolone (Cay-15013) decrease ovalbumin-induced increases in the number of eosinophils in bronchoalveolar lavage fluid (BALF) and lung tissue to a greater extent than methylprednisolone alone in a mouse model of lung inflammation. PAMAM G4.0 amidoethanol is toxic to the cyanobacteria Anabaena and green alga C. reinhardtii (EC90s = 5.13 and 1.02 mg/L, respectively) and induces the formation of reactive oxygen species (ROS) in both. Unlike PAMAM G3.0, -G4.0, -G5.0, and -G6.0-NH2, PAMAM G4.0 amidoethanol is unable to transfect cells.Synonyms: PAMAM G4.0 Amidoethanol, Polyamidoamine Dendrimer G4.0 Amidoethanol. Molecular Formula: [NH2(CH2)2NH2]:(G=4),dendri PAMAM(NHCH2CH2OH)64. Formula Weight: 14277.2. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble.