Pachymic Acid

Pachymic acid is a triterpenoid that has been found in P. cocos and has diverse biological activities. It inhibits hexokinase 2 (HK2, IC50 = 5.01 µM), as well as reduces glucose uptake and lactate production in SK-BR-3 breast cancer cells. Pachymic acid inhibits IL-1beta-induced cytosolic phospholipase A2 (cPLA2) activation and prostaglandin E2 (PGE2, Cay-14010) production in, as well as inhibits the proliferation of, A549 lung cancer cells. It decreases tumor growth in an NCI H23 lung cancer mouse xenograft model when administered at doses of 30 and 60 mg/kg. Pachymic acid (10 and 20 mg/kg) prevents increases in serum urea and creatinine levels in a mouse model of renal ischemia-reperfusion injury.Formal Name: 3beta-(acetyloxy)-16alpha-hydroxy-24-methylene-lanost-8-en-21-oic acid. CAS Number: 29070-92-6. Synonyms: 3-O-Acetyltumulosic Acid, NSC 244427. Molecular Formula: C33H52O5. Formula Weight: 528.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: C[C@]12[C@@]([C@]([C@@H](CCC(C(C)C)=C)C(O)=O)([H])[C@@H](C1)O)(CCC3=C2CC[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)OC(C)=O)C)C. InChi Code: InChI=1S/C33H52O5/c1-19(2)20(3)10-11-22(29(36)37)28-25(35)18-33(9)24-12-13-26-30(5,6)27(38-21(4)34)15-16-31(26,7)23(24)14-17-32(28,33)8/h19,22,25-28,35H,3,10-18H2,1-2,4-9H3,(H,36,37)/t22-,25-,26+,27+,28+,31-,32-,33+/m1/s1. InChi Key: VDYCLYGKCGVBHN-DRCQUEPLSA-N. Origin: Fungus/Poria cocos.