N-butyl Lithocholic Acid

N-butyl Lithocholic acid is a derivative of the secondary bile acid lithocholic acid (Cay-20253). Lipid nanoparticles (LNPs) containing N-butyl lithocholic acid and encapsulating an mRNA vaccine expressing influenza hemagglutinin exhibit less heart, spleen, and liver toxicity than LNPs containing cholesterol (Cay-9003100, Cay-39088) in mice.Formal Name: (3alpha,5beta)-3-hydroxy-cholan-24-oic acid, butyl ester. CAS Number: 135013-42-2. Synonyms: N-butyl LCA, N-butyl Lithocholate. Molecular Formula: C28H48O3. Formula Weight: 432.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble: 0.1-1 mg/ml, Ethanol: Sparingly Soluble: 1-10 mg/ml. SMILES: C[C@H](CCC(OCCCC)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C28H48O3/c1-5-6-17-31-26(30)12-7-19(2)23-10-11-24-22-9-8-20-18-21(29)13-15-27(20,3)25(22)14-16-28(23,24)4/h19-25,29H,5-18H2,1-4H3/t19-,20-,21-,22+,23-,24+,25+,27+,28-/m1/s1. InChi Key: DVARNCCRARJWLO-WQKHHYSQSA-N.