N-[1,2-Dithiolane-3-pentanoyl]-L-glutamyl-L-alanine

N-[1,2-Dithiolane-3-pentanoyl]-L-glutamyl-L-alanine is a derivative of DL-alpha-lipoic acid (Cay-10005728). It decreases infarct area in a rat model of myocardial infarction induced by ischemia and reperfusion injury when administered at doses of 1 or 2 mg/kg. N-[1,2-Dithiolane-3-pentanoyl]-L-glutamyl-L-alanine reduces hemispheric swelling, midline shift, and intracerebral hemorrhaging in a porcine model of traumatic brain injury (TBI) induced by controlled cortical impact. Formal Name: N-[5-(1,2-dithiolan-3-yl)-1-oxopentyl]-L-alpha-glutamyl-L-alanine. CAS Number: 1255918-84-3. Synonyms: CMX-2043. Molecular Formula: C16H26N2O6S2. Formula Weight: 406.5. Purity: >98%. Formulation (Request formulation change): A solid. Solubility: Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml. SMILES: OC([C@H](C)NC([C@H](CCC(O)=O)NC(CCCCC1SSCC1)=O)=O)=O. InChi Code: InChI=1S/C16H26N2O6S2/c1-10(16(23)24)17-15(22)12(6-7-14(20)21)18-13(19)5-3-2-4-11-8-9-25-26-11/h10-12H,2-9H2,1H3,(H,17,22)(H,18,19)(H,20,21)(H,23,24)/t10-,11?,12-/m0/s1. InChi Key: MQXRTCVZPIHBLD-PRWSFJOGSA-N. Storage: -20°C. Stability: > 4 years.